In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists from the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) now derived universal rules to enable the de novo design of optimal enzymes. As an example, they considered the enzymatic reaction of breaking a dimer into two monomer molecules. Considering the geometry of such an enzyme-substrate-complex, they identified three golden rules that should be considered to build a functional enzyme. First, the interface of both enzyme and molecule should be located at their respective smaller end. This way, a strong coupling between both of them can…

Open science essentials in 2 minutes, part 4 Before a research article is published in a journal you can make it freely available for anyone to read. You could do this on your own website, but you can also do it on a preprint server, such as psyarxiv.com, where other researchers also share their preprints, which is supported by the OSF so will be around for a while, and which allows you to find others’ research easily. Preprint servers have been used for decades in physics, but are now becoming more common across academia. Preprints allow rapid dissemination of your…

Dear RW readers, can you spare $25? The week at Retraction Watch featured: Our list of retracted or withdrawn COVID-19 papers is up past 500. There are more than 59,000 retractions in The Retraction Watch Database — which is now part of Crossref. The Retraction Watch Hijacked Journal Checker now contains more than 300 titles. And have you seen our leaderboard of authors with the most retractions lately — or our list of top 10 most highly cited retracted papers? What about The Retraction Watch Mass Resignations List — or our list of nearly 100 papers with evidence they were…